Endocrine Abstracts

Given the increasingly accepted increase in fracture risk that occurs in patients with type 2 diabetes, a number of strategies need to be considered reflecting the multiple factors underlying the fracture risk. These comprise measures to improve falls risk, the avoidance of treatments that may be detrimental to skeletal health and the use of treatments to maintain or improve bone strength.Older people with diabetes are at high risk of falls, recurrent fa...

Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. An individual with a hip or vertebral fracture has an excess risk of death that is highest during the first year. Moreover, all osteoporosis related fractures can lead to significant long-term disability and decreased quality of life. The ability to accurately gauge fracture risk is critical in identifying cost-effective thresholds for intervention....

A 32-year-old women initially presented with recurrent kidney stones and was found to have nephrocalcinosis. She was found to normocalcaemic but hypercalciuric, with a plasma ionized calcium at upper-limit of normal and a PTH in lower normal range. One year later, during the first trimester of a pregnancy, she presented with severe hypercalcaemia, hypercalciuria and suppression of PTH. Extensive investigations for causes of hypercalcaemia excluded hyperparathyroidism, other en...